Association of Oxcarbazepine-induced Cutaneous Adverse Drug Reactions with HLA-B*15:02 Allele
نویسندگان
چکیده
منابع مشابه
Cutaneous adverse drug reactions induced by Oxcarbazepine
Poster background Oxcarbazepine (OXC) is a structural analog of carbamazepine (CBZ). OXC is considered a promising alternative medication for patients who cannot tolerate CBZ because of its equivalent clinical effiecacy and fewer cutaneous adverse drug reactions (cADRs) compared to CBZ. HLAB*15:02 allele was shown to strongly associate with carbamazepine (CBZ)-induced Stevens-Johnson syndrome (...
متن کاملPilot association study of oxcarbazepine-induced mild cutaneous adverse reactions with HLA-B*1502 allele in Chinese Han population
BACKGROUND Recent study demonstrated that HLA-B*1502 was a common risk allele in aromatic antiepileptic drugs (AEDs) induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Han Chinese. However, the association of AEDs-induced mild maculopapular eruption (MPE) with HLA-B*1502 remains unclear until recently. In the present study, we conducted a pilot study to detect a possible associa...
متن کاملHLA Association with Drug-Induced Adverse Reactions
Adverse drug reactions (ADRs) remain a common and major problem in healthcare. Severe cutaneous adverse drug reactions (SCARs), such as Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) with mortality rate ranges from 10% to more than 30%, can be life threatening. A number of recent studies demonstrated that ADRs possess strong genetic predisposition. ADRs induced by several drugs...
متن کاملAssociation of HLA-A and HLA-B Alleles with Lamotrigine-Induced Cutaneous Adverse Drug Reactions in the Thai Population
Background: Lamotrigine (LTG) is commonly used for treatment of epilepsy and bipolar disorder. It is one of the common cause of cutaneous adverse drug reactions (CADR). Clinical symptoms of LTG-induced CADR range from maculopapular exanthema (MPE) to severe cutaneous adverse reactions (SCAR). This study aimed to determine the association of the LTG-induced CADR with human leukocyte antigen (HLA...
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ژورنال
عنوان ژورنال: Siriraj Medical Journal
سال: 2020
ISSN: 2629-995X,2228-8082
DOI: 10.33192/smj.2020.23